Structure of PDB 4hp3 Chain C

Receptor sequence
>4hp3C (length=51) Species: 8364 (Xenopus tropicalis) [Search protein sequence]
NKKRKRCGVCVPCLRKEPCGACYNCVNRSTSHQICKMRKCEQLKKKRVVP
M
3D structure
PDB4hp3 Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development.
ChainC
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C R62 H90 Q91 R96 K97 R105 M109 R4 H32 Q33 R38 K39 R47 M51 PDBbind-CN: Kd=2uM
BS02 dna C K61 K63 Y81 H90 Q91 K94 K3 K5 Y23 H32 Q33 K36 PDBbind-CN: Kd=2uM
BS03 ZN C C65 C68 C71 C98 C7 C10 C13 C40
BS04 ZN C C77 C80 C83 C93 C19 C22 C25 C35
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4hp3, PDBe:4hp3, PDBj:4hp3
PDBsum4hp3
PubMed23217707
UniProtA0JP82|TET3_XENTR Methylcytosine dioxygenase tet3 (Gene Name=tet3)

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