Structure of PDB 4haz Chain C

Receptor sequence
>4hazC (length=1014) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
AMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQ
KADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMII
SMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSV
NVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQ
VLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTR
AITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKA
TYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQ
LSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV
RPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEI
MISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLL
DLCVKKSGKDNEAVVASDIMYVVGQYPRFLKAHWNFLRTVILQLFEFMHE
THEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADL
QPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTAN
PTLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSS
MISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVL
VEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSV
FECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVD
AICWAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVS
ETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQAEVPQGTSNQ
VYLSQYLANMLSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQ
IKEVGGDPTDYLFA
3D structure
PDB4haz Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
ChainC
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBF C K525 V529 L536 C539 A552 I555 F572 T575 Q579 F583 K489 V493 L500 C503 A516 I519 F536 T539 Q543 F547
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4haz, PDBe:4haz, PDBj:4haz
PDBsum4haz
PubMed23297231
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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