Structure of PDB 4haw Chain C

Receptor sequence
>4hawC (length=1012) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GAMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAW
QKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMI
ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSS
VNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDT
RAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLK
ATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLI
QLSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM
VRPEEVLVVENDEGEIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEE
IMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDL
LDLCVKKRGKDNAAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMH
ETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTAD
LQPQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTA
LDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMIS
AQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEP
LLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFEC
TLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAIC
WAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETF
FVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVY
LSQYLANMLSNAFPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIK
EVGGDPTDYLFA
3D structure
PDB4haw Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
ChainC
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LMB C K525 C539 R543 I555 F572 T575 K579 F583 K490 C504 R508 I520 F537 T540 K544 F548
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4haw, PDBe:4haw, PDBj:4haw
PDBsum4haw
PubMed23297231
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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