Structure of PDB 4h2h Chain C

Receptor sequence
>4h2hC (length=367) Species: 314265 (Salipiger bermudensis HTCC2601) [Search protein sequence]
LKIAEIQLFQHDLPVVNGPYRIASGDVWSLTTTIVKIIAEDGTIGWGETC
PVGPTYAEAHAGGALAALEVLASGLAGAEALPLPLHTRMDSLLCGHNYAK
SALDIAVHDLWGKRLGVPVHELLGGALTDSVSSYYSLGVMEPDEAARQAL
EKQREGYSRLQVKLGARPIEIDIEAIRKVWEAVRGTGIALAADGNRGWTT
RDALRFSRECPDIPFVMEQPCNSFEDLEAIRPLCHHALYMDEDGTSLNTV
ITAAATSLVDGFGMKVSRIGGLQHMRAFRDFCAARNLPHTCDDAWGGDIV
SAACTHIASTVLPRLMEGAWLAQPYVAEHYDAENGVRIEGGRIRVPQGPG
LGLTIDPERFGPPLFSA
3D structure
PDB4h2h Discovery of new enzymes and metabolic pathways by using structure and genome context.
ChainC
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y20 S136 Q161 K163 D193 E218 D241 E242 K265 D292 D293 A294 E317 G318 A319 W320
Catalytic site (residue number reindexed from 1) Y20 S136 Q161 K163 D193 E218 D241 E242 K265 D292 D293 A294 E317 G318 A319 W320
Enzyme Commision number 5.1.1.22: 4-hydroxyproline betaine 2-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D193 E218 D241 D193 E218 D241
BS02 0XW C Y20 Y56 Q161 K163 D193 D241 K265 A294 W320 Y20 Y56 Q161 K163 D193 D241 K265 A294 W320
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016853 isomerase activity
GO:0016854 racemase and epimerase activity
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives
GO:0036361 racemase activity, acting on amino acids and derivatives
GO:0046872 metal ion binding
Biological Process
GO:0006579 amino-acid betaine catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4h2h, PDBe:4h2h, PDBj:4h2h
PDBsum4h2h
PubMed24056934
UniProtQ0FPQ4|HPBD_SALBH 4-hydroxyproline betaine 2-epimerase (Gene Name=hpbD)

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