Structure of PDB 4guv Chain C

Receptor sequence
>4guvC (length=367) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
NLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLD
LHKGSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFD
NPEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETA
DLVILANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEINCPGFFQLCNG
NRLMASHQGNLLFANPNNNGALHFGISFKTPDEWQVDFQNRNSVVDFLLK
EFSDWDERYKELIHTTLSFVGLATRIFPLEKPWKSKRPLPITMIGDAAHL
MPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEAQ
EESTQNEIEMFKPDFTF
3D structure
PDB4guv Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX.
ChainC
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.231: tetracycline 11a-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C G25 P26 V27 E46 R47 L60 R117 R137 K138 L139 N168 Q192 G310 D311 P318 G323 V324 G14 P15 V16 E35 R36 L49 R106 R126 K127 L128 N157 Q181 G295 D296 P303 G308 V309
BS02 XE C I237 F267 Y274 I278 I226 F252 Y259 I263
BS03 XE C N221 F239 F262 E266 F267 N210 F228 F247 E251 F252
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0071949 FAD binding
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4guv, PDBe:4guv, PDBj:4guv
PDBsum4guv
PubMed23999299
UniProtQ93L51|TETX_BACT4 Flavin-dependent monooxygenase (Gene Name=tetX2)

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