Structure of PDB 4gme Chain C

Receptor sequence

>4gmeC (length=403) Species: 190650 (Caulobacter vibrioides CB15)

MLKIIDAKVIVTCPGRNFVTLKITTEDGITGVGDATLNGRELSVVSFLQD
HMVPSLIGRDAHQIEDIWQFFYRGSYWRGGPVAMTALAAVDMALWDIKGK
VAGLPVYQLLGGACRTGVTVYGHANGETIEDTIAEAVKYKAMGYKAIRLQ
TGVPGLASTYGVSKDKMFYEPADNDLPTENIWSTAKYLNSVPKLFERARE
VLGWDVHLLHDVHHRLTPIEAARLGKDLEPYRLFWLEDSVPAENQAGFRL
IRQHTTTPLAVGEIFAHVWDAKQLIEEQLIDYLRATVLHAGGITNLKKIA
AFADLHHVKTGCHGATDLSPVTMAAALHFDMSITNFGLQEYMRHTPETDA
VFPHAYTFSDGMLHPGDKPGLGVDIDEDLAAKHPYKRAYLPVNRLEDGTM
FNW

3D structure

• PDB: 4gme Crystal Structure of Mannonate Dehydratase from Caulobacter Crescentus Cb15
• Chain: C
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L60 R63 D234 H236 E260 G285 E286 I287 T309 H336 A338 E363
• Catalytic site (residue number reindexed from 1): L37 R40 D211 H213 E237 G262 E263 I264 T286 H313 A315 E340
• Enzyme Commision number: 4.2.1.8: mannonate dehydratase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	C	D234 E260 E286	D211 E237 E263
BS02	CS2	C	N61 Y183 D234 H236 E260 E286 H336 D340 E363 L413 W426	N38 Y160 D211 H213 E237 E263 H313 D317 E340 L390 W403

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0008927 mannonate dehydratase activity
• GO:0016829 lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009063 amino acid catabolic process
• GO:0016052 carbohydrate catabolic process

External links

• PDB: RCSB:4gme, PDBe:4gme, PDBj:4gme
• PDBsum: 4gme
• UniProt: Q9AAR4|MAND2_CAUVC D-mannonate dehydratase CC0532 (Gene Name=CC_0532)