Structure of PDB 4gl9 Chain C

Receptor sequence
>4gl9C (length=284) Species: 10090 (Mus musculus) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL
RDFEREIEILKSLQHDNIVKYKGVCYSNLRLIMEYLPYGSLRDYLQKHKE
RIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFG
LTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE
LFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPD
EIYVIMTECWNNNVSQRPSFRDLSLRVDQIRDSI
3D structure
PDB4gl9 SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
ChainC
Resolution3.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N981 D994
Catalytic site (residue number reindexed from 1) N135 D148
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IZA C L855 K857 G858 A880 M929 E930 L983 D994 L13 K15 G16 A38 M83 E84 L137 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gl9, PDBe:4gl9, PDBj:4gl9
PDBsum4gl9
PubMed23454976
UniProtQ62120|JAK2_MOUSE Tyrosine-protein kinase JAK2 (Gene Name=Jak2)

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