Structure of PDB 4gec Chain C

Receptor sequence
>4gecC (length=259) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
GLVPRGSMILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRL
YVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGYSLGGRVAM
MAACQGLAGLCGVIVEGGHPGLQNAEQRAEAQRSDRQWVQRFLTEPLTAV
FADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRA
NLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVI
ASLAQILRF
3D structure
PDB4gec Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 C S86 L87 R90 S93 L94 R97
BS02 CL C Y85 Y148 Y92 Y155
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0070205 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gec, PDBe:4gec, PDBj:4gec
PDBsum4gec
PubMed23637813
UniProtP37355|MENH_ECOLI 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (Gene Name=menH)

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