Structure of PDB 4gdp Chain C

Receptor sequence

>4gdpC (length=488) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGR
KYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRV
DHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLT
NDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRAAFALNYDSVVQR
IAQSFPQNWLKLSCEVKSITRENVTVNCEDGTVYNADYVIITVPQSVLNL
SVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNES
SKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSTSVTCWSQPLFFVNL
SKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSED
VIDGMRNKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQD
SRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKL

3D structure

PDB

4gdp Mechanistic and Structural Analyses of the Roles of Active Site Residues in Yeast Polyamine Oxidase Fms1: Characterization of the N195A and D94N Enzymes.

Chain

Resolution

1.9998 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H67
Catalytic site (residue number reindexed from 1)	H60
Enzyme Commision number	1.5.3.17: non-specific polyamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	G15 G17 A19 E39 A40 R41 G46 R47 G62 A63 S64 W65 H67 V223 V253 P254 G270 A449 Y450 G478 E479 G487 C488 A489 A492	G8 G10 A12 E32 A33 R34 G39 R40 G55 A56 S57 W58 H60 V216 V243 P244 G260 A428 Y429 G457 E458 G466 C467 A468 A471
BS02	PG4	C	H67 L173 W174 L294 G487 C488	H60 L166 W167 L284 G466 C467

Gene Ontology

	Molecular Function
GO:0003682	chromatin binding
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0052897	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901	spermine oxidase activity
GO:0052903	N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0015940	pantothenate biosynthetic process
GO:0046208	spermine catabolic process

	Cellular Component
GO:0005737	cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4gdp, PDBe:4gdp, PDBj:4gdp
PDBsum	4gdp
PubMed	23034052
UniProt	P50264\|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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