Structure of PDB 4g8l Chain C

Receptor sequence

>4g8lC (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]

SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLH
NAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSK
GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKGGATAL
MDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAIT
HLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD
GKTALLLAVELKLKKIAELLCKRGASTDLVMTARRNYDHSLVKVLLSHGA

3D structure

PDB

4g8l Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	25A	C	E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155	E41 E43 G44 W46 Q54 K75 Y110 F112 E117 Y121 R141	BindingDB: IC50=20nM,EC50=0.210000nM
BS02	25A	C	M306 R309 R310 Y312	M281 R284 R285 Y287	BindingDB: IC50=20nM,EC50=0.210000nM

External links

PDB	RCSB:4g8l, PDBe:4g8l, PDBj:4g8l
PDBsum	4g8l
PubMed	23084743
UniProt	Q05823\|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

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