Structure of PDB 4fzb Chain C

Receptor sequence
>4fzbC (length=207) Species: 10506 (Paramecium bursaria Chlorella virus 1) [Search protein sequence]
ASMTGSAKLISVTKPVVEGVNTAEELIAYAARVSNPENQINNKTASGLLK
YCIRHKHWSIFETAFMTLELKTSRGIAAQVLRHRSFHFQEFSQRYASVME
TPPPHQARPEDDQTWWATEQEKLYAQSMELYNKALEKGIAKECARFILPL
STPTTIYMSGTIRDWIHYIELRTSNGTQREHIDLANACKEIFIKEFPSIA
KALDWVH
3D structure
PDB4fzb Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
ChainC
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C Q85 E86 Q89 E90
BS02 0VJ C E86 F87 Q89 R90 E90 F91 Q93 R94
BS03 0VJ C Q75 R182 Q188 Q79 R172 Q178
BS04 FAD C H53 S55 R173 H57 S59 R163
BS05 FAD C W54 R78 H79 S81 R173 D174 H177 W58 R82 H83 S85 R163 D164 H167
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fzb, PDBe:4fzb, PDBj:4fzb
PDBsum4fzb
PubMed23155486
UniProtO41156|THYX_PBCV1 Probable flavin-dependent thymidylate synthase (Gene Name=A674R)

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