Structure of PDB 4fj1 Chain C

Receptor sequence
>4fj1C (length=258) Species: 5503 (Curvularia lunata) [Search protein sequence]
PGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSE
IKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHL
KDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVP
KHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHY
IPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKV
LTLDGGAA
3D structure
PDB4fj1 Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 S153 N154 H164 Y167 K171 Y212
Catalytic site (residue number reindexed from 1) G17 S141 N142 H152 Y155 K159 Y200
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G25 R28 G29 I30 A50 N51 S52 I77 N103 S104 G105 L126 T151 S153 Y167 K171 P197 G198 G199 T200 T202 M204 G13 R16 G17 I18 A38 N39 S40 I65 N91 S92 G93 L114 T139 S141 Y155 K159 P185 G186 G187 T188 T190 M192
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

View graph for
Molecular Function
External links
PDB RCSB:4fj1, PDBe:4fj1, PDBj:4fj1
PDBsum4fj1
PubMed28259640
UniProtO93874

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