Structure of PDB 4fj0 Chain C

Receptor sequence
>4fj0C (length=259) Species: 5503 (Curvularia lunata) [Search protein sequence]
IPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVS
EIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGH
LKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSV
PKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHH
YIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGK
VLTLDGGAA
3D structure
PDB4fj0 Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 S153 N154 H164 Y167 K171 Y212
Catalytic site (residue number reindexed from 1) G18 S142 N143 H153 Y156 K160 Y201
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G25 R28 G29 I30 A50 N51 S52 I77 N103 S104 G105 L126 T151 Y167 K171 P197 G198 G199 T200 T202 M204 G14 R17 G18 I19 A39 N40 S41 I66 N92 S93 G94 L115 T140 Y156 K160 P186 G187 G188 T189 T191 M193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

View graph for
Molecular Function
External links
PDB RCSB:4fj0, PDBe:4fj0, PDBj:4fj0
PDBsum4fj0
PubMed28259640
UniProtO93874

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