Structure of PDB 4f9b Chain C

Receptor sequence
>4f9bC (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
LAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEK
IALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPY
LEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYN
RRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQRAGTPGFRAPEVLTKCP
NQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQA
AKTFGKSILCSKEVPAQDLRKLCERLRGWNEVPDEAYDLLDKLLDLNPAS
RITAEEALLHPFFKDM
3D structure
PDB4f9b Crystal structure of human CDC7 kinase in complex with its activator DBF4.
ChainC
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D141 K143 N146 D160 T187
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 0SY C V72 A88 K90 L137 L184 V195 D196 V36 A52 K54 L101 L148 V159 D160 BindingDB: IC50=10nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4f9b, PDBe:4f9b, PDBj:4f9b
PDBsum4f9b
PubMed23064647
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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