Structure of PDB 4f9a Chain C

Receptor sequence
>4f9aC (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
LAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEK
IALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPY
LEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYN
RRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQRAGTPGFRAPEVLTKC
PNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQ
AAKTFGKSILCSKEVPAQDLRKLCERLRGWNEVPDEAYDLLDKLLDLNPA
SRITAEEALLHPFFKDM
3D structure
PDB4f9a Crystal structure of human CDC7 kinase in complex with its activator DBF4.
ChainC
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D141 K143 N146 D160 T188
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C G67 S70 V72 K90 M118 M134 Y136 L137 H139 S181 L184 D196 G31 S34 V36 K54 M82 M98 Y100 L101 H103 S145 L148 D160
BS02 MG C N182 D196 N146 D160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4f9a, PDBe:4f9a, PDBj:4f9a
PDBsum4f9a
PubMed23064647
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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