Structure of PDB 4f2d Chain C

Receptor sequence

>4f2dC (length=498) Species: 83333 (Escherichia coli K-12)

MTIFDNYEVWFVIGSQHLYGPETLRQVTQHAEHVVNALNTEAKLPCKLVL
KPLGTTPDEITAICRDANYDDRCAGLVVWLHTFSPAKMWINGLTMLNKPL
LQFHTQFNAALPWDSIDMDFMNLNQTAHGGREFGFIGARMRQQHAVVTGH
WQDKQAHERIGSWMRQAVSKQDTRHLKVCRFGDNMREVAVTDGDKVAAQI
KFGFSVNTWAVGDLVQVVNSISDGDVNALVDEYESCYTMTPATQIHGEKR
QNVLEAARIELGMKRFLEQGGFHAFTTTFEDLHGLKQLPGLAVQRLMQQG
YGFAGEGDWKTAALLRIMKVMSTGLQGGTSFMEDYTYHFEKGNDLVLGSH
MLEVCPSIAVEEKPILDVQHLGIGGKDDPARLIFNTQTGPAIVASLIDLG
DRYRLLVNCIDTVKTPHSLPKLPVANALWKAQPDLPTASEAWILAGGAHH
TVFSHALNLNDMRQFAEMHDIEITVIDNDTRLPAFKDALRWNEVYYGF

3D structure

• PDB: 4f2d Crystal Structure of Escherichia coli L-arabinose Isomerase (ECAI) complexed with Ribitol
• Chain: C
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 5.3.1.4: L-arabinose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	C	E306 E333 H350 H450	E306 E333 H350 H450
BS02	RB0	C	M185 F279 E306 E333 H449	M185 F279 E306 E333 H449

Gene Ontology

Molecular Function

• GO:0008733 L-arabinose isomerase activity
• GO:0016853 isomerase activity
• GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0005996 monosaccharide metabolic process
• GO:0019568 arabinose catabolic process
• GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4f2d, PDBe:4f2d, PDBj:4f2d
• PDBsum: 4f2d
• UniProt: P08202|ARAA_ECOLI L-arabinose isomerase (Gene Name=araA)