Structure of PDB 4eb9 Chain C

Receptor sequence
>4eb9C (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCD
GGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
ST
3D structure
PDB4eb9 Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C300 C303 H320 C327 C46 C49 H66 C73
BS02 0O6 C D297 G306 L307 R308 C309 W310 E311 D314 E319 W323 D43 G52 L53 R54 C55 W56 E57 D60 E65 W69 PDBbind-CN: -logKd/Ki=8.27,IC50=5.4nM
BindingDB: IC50=5.4nM
External links
PDB RCSB:4eb9, PDBe:4eb9, PDBj:4eb9
PDBsum4eb9
PubMed23166698
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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