Structure of PDB 4eak Chain C

Receptor sequence
>4eakC (length=285) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SNSSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAP
LWDSKKQSFVGMLTITDFINILHRELEEHKIETWREVYLQDSFKPLVCIS
PNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEF
PKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDE
KGRVVDIYSKFDVINLAAEKTNLDVSVTKALQHRSVLKCYLHETLEAIIN
RLVEAEVHRLVVVDEHDVVKGIVSLSDILQALVLT
3D structure
PDB4eak AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C M84 T86 I87 T88 D89 Q122 L128 V129 I149 H150 R151 M62 T64 I65 T66 D67 Q90 L96 V97 I117 H118 R119
BS02 ATP C H150 T199 I203 A204 V224 S225 H297 I311 S313 L314 S315 D316 H118 T167 I171 A172 V192 S193 H258 I272 S274 L275 S276 D277
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0031669 cellular response to nutrient levels
GO:0051170 import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031588 nucleotide-activated protein kinase complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4eak, PDBe:4eak, PDBj:4eak
PDBsum4eak
PubMed22659875
UniProtP80385|AAKG1_RAT 5'-AMP-activated protein kinase subunit gamma-1 (Gene Name=Prkag1)

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