Structure of PDB 4e5k Chain C

Receptor sequence
>4e5kC (length=328) Species: 316 (Stutzerimonas stutzeri) [Search protein sequence]
MLPKLVITHRVHEEILQLLAPHCELITNQTDSTLTREEILRRCRDAQAMM
AFMPDRVDADFLQACPELRVIGCALKGFDNFDVDACTARGVWLTFVPDLL
TVPTAELAIGLAVGLGRHLRAADAFVRSGKFRWQPRFYGTGLDNATVGFL
GMGAIGLAMADRLQGWGATLQYHEAKALDTQTEQRLGLRQVACSELFASS
DFILLALPLNADTLHLVNAELLALVRPGALLVNPCRGSVVDEAAVLAALE
RGQLGGYAADVFEMEDWARADRPQQIDPALLAHPNTLFTPHIGSAVRAVR
LEIERCAAQNILQALAGERPINAVNRLP
3D structure
PDB4e5k Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.
ChainC
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L100 R237 D261 E266 H292
Catalytic site (residue number reindexed from 1) L100 R236 D260 E265 H291
Enzyme Commision number 1.20.1.1: phosphonate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C K76 G77 L100 T104 G154 A155 I156 H174 E175 A176 L208 P209 P235 C236 R237 K76 G77 L100 T104 G153 A154 I155 H173 E174 A175 L207 P208 P234 C235 R236
BS02 SO3 C M53 K76 G77 R237 H292 M53 K76 G77 R236 H291
Gene Ontology
Molecular Function
GO:0008465 hydroxypyruvate reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030267 glyoxylate reductase (NADPH) activity
GO:0050609 phosphonate dehydrogenase activity
GO:0051287 NAD binding
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4e5k, PDBe:4e5k, PDBj:4e5k
PDBsum4e5k
PubMed22564171
UniProtO69054|PTXD_STUST Phosphonate dehydrogenase (Gene Name=ptxD)

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