Structure of PDB 4e5f Chain C

Receptor sequence

>4e5fC (length=182) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1)))

MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD
GGSKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIE
IGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRA
RIKTRLFTIRQEMASRGLWDSFRQSERAAAEL

3D structure

• PDB: 4e5f Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
• Chain: C
• Resolution: 2.392 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	C	H41 D108 E119 I120	H41 D89 E100 I101
BS02	MN	C	E80 P107 D108	E61 P88 D89
BS03	0N7	C	H41 D108 E119 K134	H41 D89 E100 K115	MOAD: ic50=15uM

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4e5f, PDBe:4e5f, PDBj:4e5f
• PDBsum: 4e5f
• PubMed: 22876176
• UniProt: Q5EP34