Structure of PDB 4dwr Chain C

Receptor sequence
>4dwrC (length=481) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
VVPLKRIDKIRWEIPKFDKRMRVPGRVYADEVLLEKMKNDRTLEQATNVA
MLPGIYKYSIVMPDGHQGYGFPIGGVAAFDVKEGVISPGGIGYDINCGVR
LIRTNLTEKEVRPRIKQLVDTLFKNVPSGVRIKLHWTQIDDVLVDGAKWA
VDNGYGWERDLERLEEGGRMEGADPEAVSQRAKQRGAPQLGSLGSGNHFL
EVQVVDKIFDPEVAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERA
IRKYRIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRE
SFQEVFKQDPEGDLGMDIVYDVAHNIGKVEEHEVDGKRVKVIVHRKGATR
AFPPGHEAVPRLYRDVGQPVLIPGSMGTASYILAGTEGAMKETFGSTCHG
AGRVLSRKAATRQYRGDRIRQELLNRGIYVRAASMRVVAEEAPGAYKNVD
NVVKVVSEAGIAKLVARMRPIGVAKGAAALE
3D structure
PDB4dwr Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH.
ChainC
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
6.5.1.8: 3'-phosphate/5'-hydroxy nucleic acid ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC C K17 R23 K16 R22
BS02 FRU C Y57 K58 D340 Y56 K57 D335
BS03 MN C C98 H234 H329 C97 H229 H324
BS04 MN C D95 C98 H203 D94 C97 H198
Gene Ontology
Molecular Function
GO:0008452 RNA ligase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4dwr, PDBe:4dwr, PDBj:4dwr
PDBsum4dwr
PubMed22949672
UniProtO59245|RTCB_PYRHO tRNA-splicing ligase RtcB (Gene Name=rtcB)

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