Structure of PDB 4dk8 Chain C

Receptor sequence
>4dk8C (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRPKVTPWPLDARQQRFAHFTELAIISVQ
EIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFL
KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS
ADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRT
LSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB4dk8 Discovery of a new binding mode for a series of liver X receptor agonists.
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Q280 V283 K287 R297 E298 I301 K305 L452 E455 I456 Q50 V53 K57 R67 E68 I71 K75 L222 E225 I226
BS02 0KT C F271 L274 M312 T316 F329 L345 H435 F41 L44 M82 T86 F99 L115 H205
BS03 CA C N239 E315 N21 E85
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dk8, PDBe:4dk8, PDBj:4dk8
PDBsum4dk8
PubMed22406115
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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