Structure of PDB 4dk7 Chain C

Receptor sequence
>4dk7C (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRPKVTPWPLDARQQRFAHFTELAIISVQ
EIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFL
KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS
ADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRT
LSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB4dk7 Discovery of a new binding mode for a series of liver X receptor agonists.
ChainC
Resolution2.45 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Q280 V283 K287 R297 E298 I301 K305 L452 E455 Q50 V53 K57 R67 E68 I71 K75 L222 E225
BS02 0KS C T272 L274 A275 S278 M312 T316 F329 H435 W457 T42 L44 A45 S48 M82 T86 F99 H205 W227 MOAD: ic50=0.02uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4dk7, PDBe:4dk7, PDBj:4dk7
PDBsum4dk7
PubMed22406115
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

[Back to BioLiP]