Structure of PDB 4d11 Chain C

Receptor sequence
>4d11C (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
SKVRWPDFNQEAYVGGPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQW
RVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDP
EDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNE
HWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFK
WDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVW
GGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPGTVFARNTRRAAEVW
MDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELR
VPDHQDIAFGALQQGTNCLDTLGHVYECGNQEWALTKEKSVKHMDLCLTV
VDRKLQGCREDDSRQKWEQIEGNSKLRHVWKFTLNL
3D structure
PDB4d11 Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
ChainC
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C A266 S267 L270 F280 W282 W331 F361 R362 H365 A185 S186 L189 F199 W201 W250 F280 R281 H284
BS02 MN C D224 H226 H359 D143 H145 H278
BS03 UDP C T143 R201 D224 S225 H226 W331 H359 T62 R120 D143 S144 H145 W250 H278
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
GO:0051604 protein maturation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4d11, PDBe:4d11, PDBj:4d11
PDBsum4d11
PubMed24954443
UniProtQ10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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