Structure of PDB 4d0l Chain C

Receptor sequence
>4d0lC (length=476) Species: 9606 (Homo sapiens) [Search protein sequence]
SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLP
QLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSSRGTKL
RKLILSDRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKL
PARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTS
VPARIPENPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCG
DDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNA
VSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYL
LQVKDRHNGNILLDAEGHIIHIDFGFILSSSPSAFKLTTEFVDVMGGLDG
DMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLK
ERFHMSMTEEQLQLLVEQMVDGSMRS
3D structure
PDB4d0l Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
ChainC
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 093 C P381 I547 K549 Y583 I595 P597 V598 L663 I673 D674 P183 I246 K248 Y282 I294 P296 V297 L362 I372 D373 BindingDB: IC50=19nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4d0l, PDBe:4d0l, PDBj:4d0l
PDBsum4d0l
PubMed24876499
UniProtQ9UBF8|PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (Gene Name=PI4KB)

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