Structure of PDB 4d09 Chain C

Receptor sequence
>4d09C (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
DGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCP
TLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIF
ALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAI
LNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVG
YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLE
KAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYER
VASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB4d09 Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement.
ChainC
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 788 C L770 L774 L809 M847 F862 L183 L187 L222 M260 F275 MOAD: ic50=1.7nM
BS02 ZN C H660 H696 D697 D808 H73 H109 D110 D221
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4d09, PDBe:4d09, PDBj:4d09
PDBsum4d09
PubMed25221665
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

[Back to BioLiP]