Structure of PDB 4d08 Chain C

Receptor sequence
>4d08C (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTL
ARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFAL
FISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILN
THGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYD
RNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKA
MGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVA
SNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB4d08 Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement.
ChainC
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H660 H696 D697 D808 H71 H107 D108 D219
BS02 Q2T C T768 D808 I826 F830 M845 M847 M848 Q859 F862 T179 D219 I237 F241 M256 M258 M259 Q270 F273 MOAD: ic50=10nM
BindingDB: IC50=10.0nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4d08, PDBe:4d08, PDBj:4d08
PDBsum4d08
PubMed25221665
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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