Structure of PDB 4cqo Chain C

Receptor sequence
>4cqoC (length=516) Species: 9606 (Homo sapiens) [Search protein sequence]
YDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKT
DDLITRFFRLCTEMCVEISYRAQAEQQHNPTMIRAKCYHNLDAFVRLIAL
LVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFI
MLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHR
IFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGT
LRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDP
FTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSD
LRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHS
AHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEA
NTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHC
APEIEKLFQSVAQCCM
3D structure
PDB4cqo Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression
ChainC
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R1929 H1991 R1992 L1999 E2040 H2044 R84 H146 R147 L154 E195 H199
BS02 peptide C K2331 W2338 F2353 A2357 M2361 K486 W493 F508 A512 M516
Gene Ontology
Biological Process
GO:0017148 negative regulation of translation
Cellular Component
GO:0030015 CCR4-NOT core complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4cqo, PDBe:4cqo, PDBj:4cqo
PDBsum4cqo
PubMed24736845
UniProtA5YKK6|CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (Gene Name=CNOT1)

[Back to BioLiP]