Structure of PDB 4cku Chain C

Receptor sequence
>4ckuC (length=322) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAG
CLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYK
FIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIEN
ALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHV
GNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNN
SKLPTFEFTSENGKYTLEPEYYLQHILCMLNIIGLDFPVPTFILGDPFMR
KYFTVFDYDNHSVGIALAKKNL
3D structure
PDB4cku Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit.
ChainC
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D33 S36 N38 W40 Y76 D213 T216
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P2F C M15 I32 D34 G36 Y77 V78 F111 I123 Y192 D214 G216 S218 L292 I300 M14 I31 D33 G35 Y76 V77 F110 I122 Y191 D213 G215 S217 L285 I293 MOAD: ic50=0.15uM
BindingDB: IC50=150nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4cku, PDBe:4cku, PDBj:4cku
PDBsum4cku
PubMed24900843
UniProtP46925|PLM2_PLAFX Plasmepsin II (Gene Name=PMII)

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