Structure of PDB 4cdf Chain C

Receptor sequence
>4cdfC (length=68) Species: 9606 (Homo sapiens) [Search protein sequence]
PFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGT
DECAIESIAVAATPIPKL
3D structure
PDB4cdf Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H381 N403
Catalytic site (residue number reindexed from 1) H10 N32
Enzyme Commision number 3.4.14.1: dipeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W2C C T379 N380 T8 N9
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4cdf, PDBe:4cdf, PDBj:4cdf
PDBsum4cdf
PubMed24592859
UniProtP53634|CATC_HUMAN Dipeptidyl peptidase 1 (Gene Name=CTSC)

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