Structure of PDB 4c2j Chain C

Receptor sequence
>4c2jC (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]
HMALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPE
TVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSI
VNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLW
VSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYF
NDEMAPIEVKKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGV
ADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGA
LKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHP
LGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQST
3D structure
PDB4c2j The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C92 H352 C382 G384
Catalytic site (residue number reindexed from 1) C93 H349 C379 G381
Enzyme Commision number 2.3.1.16: acetyl-CoA C-acyltransferase.
2.3.1.9: acetyl-CoA C-acetyltransferase.
3.1.2.-
3.1.2.1: acetyl-CoA hydrolase.
3.1.2.2: palmitoyl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA C W149 R224 A247 S251 A322 F323 H352 W150 R221 A244 S248 A319 F320 H349
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003986 acetyl-CoA hydrolase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016787 hydrolase activity
GO:0047617 fatty acyl-CoA hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006695 cholesterol biosynthetic process
GO:0071456 cellular response to hypoxia
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c2j, PDBe:4c2j, PDBj:4c2j
PDBsum4c2j
PubMed25478839
UniProtP42765|THIM_HUMAN 3-ketoacyl-CoA thiolase, mitochondrial (Gene Name=ACAA2)

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