Structure of PDB 4bzc Chain C

Receptor sequence

>4bzcC (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4bzc Mechanism of Allosteric Activation of Samhd1 by Dgtp

Chain

Resolution

2.88 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	T8T	C	R333 R352 K354 K523	R215 R234 K236 K405
BS02	T8T	C	V117 N119	V5 N7
BS03	T8T	C	K116 I118 D137 R145	K4 I6 D25 R33
BS04	T8T	C	Q149 L150 R164 D207 H210 H215 H233 D311 K312 Y315 D319 Y374 Q375	Q37 L38 R52 D95 H98 H103 H121 D193 K194 Y197 D201 Y256 Q257
BS05	MN	C	H167 H206 D207 D311	H55 H94 D95 D193
BS06	T8T	C	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS07	T8T	C	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337

External links

PDB	RCSB:4bzc, PDBe:4bzc, PDBj:4bzc
PDBsum	4bzc
PubMed	24141705
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]