Structure of PDB 4bo6 Chain C

Receptor sequence
>4bo6C (length=249) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
HHHHHHSSNLYFQSMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTA
TSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIV
VNNAGITRDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGGAMGN
AGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEA
QREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS
3D structure
PDB4bo6 Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G16 Y154 K158
Catalytic site (residue number reindexed from 1) G30 Y156 K160
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 36P C V110 N111 L114 G160 F164 V115 N116 L119 G162 F166
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4bo6, PDBe:4bo6, PDBj:4bo6
PDBsum4bo6
PubMed24015914
UniProtO54438|FABG_PSEAE 3-oxoacyl-[acyl-carrier-protein] reductase FabG (Gene Name=fabG)

[Back to BioLiP]