Structure of PDB 4blb Chain C

Receptor sequence

>4blbC (length=725) Species: 9606,83333 [Search protein sequence]

GKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATG
DGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLI
AYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEP
YFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHM
NADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQP
SKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVAL
KSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGR
QTVDAALAAAQTNAAAPGLHAIYGECRRLYPDQPNPLQVTAIVKYDSFGP
DPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSG
FGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHS
PLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWN
GQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSN
LSGVSAKCAWDDLPIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFT
YKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLED
ALPKEYSWPEKKLKVSIVEHHHHHH

3D structure

PDB

4blb Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	Y487 F495 D499 H500 V501 S502 W503 H504 N605 L606 S607 G608 V609 S610 E641	Y482 F490 D494 H495 V496 S497 W498 H499 N600 L601 S602 G603 V604 S605 E630
BS02	GLC	C	D15 K16 E112 Y156 W231	D10 K11 E107 Y151 W226
BS03	GLC	C	W63 D66 E154 P155 Y156 W341	W58 D61 E149 P150 Y151 W336
BS04	ZN	C	H216 E222	H211 E217
BS05	ZN	C	H751 H753	H723 H725

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4blb, PDBe:4blb, PDBj:4blb
PDBsum	4blb
PubMed	24311597
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q9UMX1\|SUFU_HUMAN Suppressor of fused homolog (Gene Name=SUFU)

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