Structure of PDB 4bks Chain C

Receptor sequence
>4bksC (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNQPIFANITLPVYTLKERCLQ
VVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLT
3D structure
PDB4bks Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X6C C W88 Y98 P99 I109 H110 S111 Y112 H115 W117 W27 Y37 P38 I48 H49 S50 Y51 H54 W56 MOAD: Kd=150uM
PDBbind-CN: -logKd/Ki=3.82,Kd=150uM
BindingDB: Kd=150000nM
External links
PDB RCSB:4bks, PDBe:4bks, PDBj:4bks
PDBsum4bks
PubMed24436777
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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