Structure of PDB 4bbh Chain C

Receptor sequence

>4bbhC (length=367) Species: 5855 (Plasmodium vivax) [Search protein sequence]

DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVC
DVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWH
IGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAP
VLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGF
VEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPI
ENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTA
TFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLY
NWKCASFAPAHVGIVLL

3D structure

PDB

4bbh Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferase.

Chain

Resolution

1.63 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N161 F162 L163 T197 L410
Catalytic site (residue number reindexed from 1)	N135 F136 L137 T171 L367
Enzyme Commision number	2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NHW	C	Y28 F30 W31 Y95 V96 N161 L163 C164 V165 R170 S171 R173 L174 A175 P176 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393	Y2 F4 W5 Y69 V70 N135 L137 C138 V139 R144 S145 R147 L148 A149 P150 T157 I160 W166 Q167 A168 Y170 T171 A172 L176 Y350
BS02	YBN	C	D98 F105 Y107 Y211 Y315 Y334 N365 A366 L367 V408 L410	D72 F79 Y81 Y185 Y272 Y291 N322 A323 L324 V365 L367	MOAD: Ki=0.08uM
BS03	MG	C	S171 K172 L174	S145 K146 L148

Gene Ontology

	Molecular Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
GO:0016746	acyltransferase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006499	N-terminal protein myristoylation
GO:0018008	N-terminal peptidyl-glycine N-myristoylation

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4bbh, PDBe:4bbh, PDBj:4bbh
PDBsum	4bbh
PubMed	23170970
UniProt	A5K1A2

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