Structure of PDB 4b9k Chain C

Receptor sequence
>4b9kC (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNQPIFANITLPVYTLKERCLQ
VVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLT
3D structure
PDB4b9k Small-Molecule Inhibitors of the Interaction between the E3 Ligase Vhl and Hif1 Alpha
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TG0 C W88 F91 Y98 P99 R107 I109 H110 S111 Y112 H115 W117 W27 F30 Y37 P38 R46 I48 H49 S50 Y51 H54 W56 MOAD: Ki=0.67uM
PDBbind-CN: -logKd/Ki=6.17,Ki=0.67uM
BindingDB: IC50=900nM
External links
PDB RCSB:4b9k, PDBe:4b9k, PDBj:4b9k
PDBsum4b9k
PubMed23065727
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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