Structure of PDB 4b8z Chain C

Receptor sequence

>4b8zC (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]

MRILVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKDADLTDTAQTRAL
FEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGAR
KVVSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAY
FQQYGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHKVHLAKSSGSALTV
WGTGNPRRQFIYSLDLAQLFIWVLREYNEVEPIILSVGEEDEVSIKEAAE
AVVEAMDFHGEVTFDTTKSDGQFKKTASNSKLRTYLPDFRFTPFKQAVKE
TCAWFTDNYEQAR

3D structure

PDB

4b8z Crystal Structure of Human Gdp-L-Fucose Synthase with Bound Nadp and Gdp, Rhombohedral Crystal Form

Chain

Resolution

2.75 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S114 T115 C116 Y143 K147 H186
Catalytic site (residue number reindexed from 1)	S107 T108 C109 Y136 K140 H179
Enzyme Commision number	1.1.1.271: GDP-L-fucose synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	C	G14 S16 G17 L18 S43 A46 L48 L69 A70 V73 M93 C112 S114 Y143 K147 T171 V173 H186 R320	G7 S9 G10 L11 S36 A39 L41 L62 A63 V66 M86 C105 S107 Y136 K140 T164 V166 H179 R313
BS02	GDP	C	G75 L76 F77 H186 V187 K194 W208 R215 S276 D277 K282	G68 L69 F70 H179 V180 K187 W201 R208 S269 D270 K275

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016853	isomerase activity
GO:0042356	GDP-4-dehydro-D-rhamnose reductase activity
GO:0042802	identical protein binding
GO:0047918	GDP-mannose 3,5-epimerase activity
GO:0050577	GDP-L-fucose synthase activity

	Biological Process
GO:0007159	leukocyte cell-cell adhesion
GO:0009226	nucleotide-sugar biosynthetic process
GO:0010595	positive regulation of endothelial cell migration
GO:0019673	GDP-mannose metabolic process
GO:0042351	'de novo' GDP-L-fucose biosynthetic process
GO:1904906	positive regulation of endothelial cell-matrix adhesion via fibronectin

	Cellular Component
GO:0005829	cytosol
GO:0070062	extracellular exosome

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4b8z, PDBe:4b8z, PDBj:4b8z
PDBsum	4b8z
PubMed
UniProt	Q13630\|FCL_HUMAN GDP-L-fucose synthase (Gene Name=GFUS)

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