Structure of PDB 4awj Chain C

Receptor sequence
>4awjC (length=136) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVPIFANITLPVYTLKERCLQ
VVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLER
3D structure
PDB4awj Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
ChainC
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V6F C W88 Y98 H110 S111 Y112 H115 W117 W27 Y37 H49 S50 Y51 H54 W56 MOAD: Kd~10000uM
PDBbind-CN: -logKd/Ki=2.00,Kd~10000uM
BindingDB: Kd=4900000nM
External links
PDB RCSB:4awj, PDBe:4awj, PDBj:4awj
PDBsum4awj
PubMed23102223
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

[Back to BioLiP]