Structure of PDB 4awf Chain C

Receptor sequence
>4awfC (length=186) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
MAMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMY
SDFHFISIIVNALLKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPD
LYDYKENRFIEIGVTRREVHIYYLEKANKIKTHIHIFSFTGEEMATKADY
TLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERG
3D structure
PDB4awf Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C E80 D108 E72 D100
BS02 MN C H41 D108 E119 I120 H43 D100 E111 I112
BS03 XI7 C H41 E80 R84 D108 E119 K134 H43 E72 R76 D100 E111 K126 MOAD: ic50=2.7uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4awf, PDBe:4awf, PDBj:4awf
PDBsum4awf
PubMed22876177
UniProtC3W5S0

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