Structure of PDB 4alh Chain C

Receptor sequence
>4alhC (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT
IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQ
KVASMPQ
3D structure
PDB4alh Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides.
ChainC
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A9P C P98 F99 L108 N156 P23 F24 L33 N81 BindingDB: IC50=34300nM
External links
PDB RCSB:4alh, PDBe:4alh, PDBj:4alh
PDBsum4alh
PubMed22136469
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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