Structure of PDB 4a5y Chain C

Receptor sequence
>4a5yC (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTME
GERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNE
ELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK
GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL
AGSENRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLG
GRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
3D structure
PDB4a5y Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
ChainC
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C R26 P27 G108 G110 K111 T112 F113 E118 R10 P11 G92 G94 K95 T96 F97 E102
BS02 G7X C E116 G117 E118 R119 W127 I136 P137 L160 Y211 L214 G217 A218 R221 E100 G101 E102 R103 W111 I120 P121 L144 Y195 L198 G201 A202 R205 BindingDB: Ki=2.3nM,IC50=47nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4a5y, PDBe:4a5y, PDBj:4a5y
PDBsum4a5y
PubMed23658017
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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