Structure of PDB 3x2e Chain C

Receptor sequence
>3x2eC (length=401) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
ANTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLA
ITLSKLGAKVVITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENL
MKVLDERPDFIIDDGGDLTVISHTEREEVLENLKGVSEETTTGVRRLKAL
EETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVV
VAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVMPMKEAVK
IADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVE
KFEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIF
AVLYLLENHRKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYL
R
3D structure
PDB3x2e Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima.
ChainC
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H42 G65 S70 D115 E140 N165 K170 D174 N175 T179 H285 H337 S345 Q349
Catalytic site (residue number reindexed from 1) H41 G64 S69 D114 E139 N164 K169 D173 N174 T178 H284 H336 S344 Q348
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI C D174 N175 G204 G206 W207 C208 T226 E227 V228 K232 S260 A283 G284 L328 N330 D173 N174 G203 G205 W206 C207 T225 E226 V227 K231 S259 A282 G283 L327 N329
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0033353 S-adenosylmethionine cycle
GO:0071269 L-homocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3x2e, PDBe:3x2e, PDBj:3x2e
PDBsum3x2e
PubMed25791616
UniProtO51933|SAHH_THEMA Adenosylhomocysteinase (Gene Name=ahcY)

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