Structure of PDB 3wxk Chain C

Receptor sequence

>3wxkC (length=513) Species: 31285 (Trypanosoma brucei gambiense)

FTMKYVGSIDQGTTSTRFIIFDERQRPVSVHQVPHTQHTPHPGWLEHDPM
EIFRSACKCMSVAIAKLRQKDASFRKIEAIGITNQRETTVAWDRVTKEPL
CYAPVWNDLRTYDITKKVTAELGGGDSMFASKITGLPVSTYFAAFKMRWM
LENVPAVADACRRGTLCFGTIDTWLMYKLSGGKAFVTDVTNASRTFLMDL
RTRKWSPELCEKLKIPMETLPEIRSNSELFGYVETDECGVAAALNERTPI
MGSIGDQQSALFGNMCFEKGEAKNTYGTGCFLLMNVGEEARFSKHGLLST
VGFQVGRDGPCYYALEGAIACAGATVEWMRRNMNLFSHITECEKLARSVP
GTQGIVFVPAFSGLLAPYWDPSARGTIVGMTLKTTRAHVIRAALQAIALQ
LNDVVGSMKRDAGLNLSSLRVDGGLSKNGLLMEIQASLLGVDILVPSMHE
TTALGAALCAGLAAGVWTSLEEVKAVSRRENSWKTVSPSGSAMEREAMIA
EWREALKRTKWAK

3D structure

• PDB: 3wxk Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase.
• Chain: C
• Resolution: 2.37 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.30: glycerol kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GOL	C	R84 E85 W104 D254	R86 E87 W106 D256

Gene Ontology

Molecular Function

• GO:0004370 glycerol kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0016773 phosphotransferase activity, alcohol group as acceptor

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006071 glycerol metabolic process
• GO:0006072 glycerol-3-phosphate metabolic process
• GO:0006641 triglyceride metabolic process
• GO:0016310 phosphorylation
• GO:0019563 glycerol catabolic process
• GO:0046167 glycerol-3-phosphate biosynthetic process

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:3wxk, PDBe:3wxk, PDBj:3wxk
• PDBsum: 3wxk
• PubMed: 25315291
• UniProt: D3KVM3