Structure of PDB 3wtx Chain C

Receptor sequence
>3wtxC (length=103) Species: 9606 (Homo sapiens) [Search protein sequence]
PIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPK
MNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAML
DVK
3D structure
PDB3wtx A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C Q336 L337 W375 K379 K381 K383 M384 K388 R391 Y396 Q3 L4 W42 K46 K48 K50 M51 K55 R58 Y63
BS02 dna C P334 R391 R394 Y397 K404 Y410 P1 R58 R61 Y64 K71 Y77
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3wtx, PDBe:3wtx, PDBj:3wtx
PDBsum3wtx
PubMed25083921
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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