Structure of PDB 3wtp Chain C

Receptor sequence
>3wtpC (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
AKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNI
QAVLLPK
3D structure
PDB3wtp Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3
ChainC
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C A14 K15 T16 R17 R20 G28 R32 R42 R77 A3 K4 T5 R6 R9 G17 R21 R31 R66
BS02 dna C R29 R42 V43 G44 A45 K75 T76 R77 R18 R31 V32 G33 A34 K64 T65 R66
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wtp, PDBe:3wtp, PDBj:3wtp
PDBsum3wtp
PubMed25408271
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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