Structure of PDB 3wlf Chain C

Receptor sequence
>3wlfC (length=333) Species: 5480 (Candida parapsilosis) [Search protein sequence]
IPSSQYGFVFNKQSGLKLRNDLPVHKPKAGQLLLKVDAVGLCHSDLHVIY
EGLDCGDNYVMGHEIAGTVAAVGDDVINYKVGDRVACVGPNGCGGCKYCR
GAIDNVCKNAFGDWFGLGYDGGYQQYLLVTRPRNLSRIPDNVSADVAAAS
TDAVLTPYHAIKMAQVSPTSNILLIGAGGLGGNAIQVAKAFGAKVTVLDK
KKEARDQAKKLGADAVYETLPESISPGSFSACFDFVSVQATFDVCQKYVE
PKGVIMPVGLGAPNLSFNLGDLALREIRILGSFWGTTNDLDDVLKLVSEG
KVKPVVRSAKLKELPEYIEKLRNNAYGRVVFNP
3D structure
PDB3wlf Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C44 H45 S46 H49 H65 E66 C95 C98 C101 C109 F113 D154 T158 R331
Catalytic site (residue number reindexed from 1) C42 H43 S44 H47 H63 E64 C93 C96 C99 C107 F111 D152 T156 R328
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEH C S46 L119 D154 W286 S44 L117 D152 W284
BS02 ZN C C98 C101 C109 C96 C99 C107
BS03 ZN C C44 H65 E66 D154 C42 H63 E64 D152
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3wlf, PDBe:3wlf, PDBj:3wlf
PDBsum3wlf
PubMed24834985
UniProtA1X808

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