Structure of PDB 3wi6 Chain C

Receptor sequence
>3wi6C (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML
QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE
LFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK
RPNAILKLTDFGFAKETTSPYYVAPEVLGPEDKSCDMWSLGVIMYILLCG
YPPFYSISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM
TITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE
3D structure
PDB3wi6 Structure of the beta-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090
ChainC
Resolution2.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 S216
Catalytic site (residue number reindexed from 1) D139 K141 E143 N144 D160 S169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YRZ C E139 L141 E190 N191 L193 D207 E94 L96 E143 N144 L146 D160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3wi6, PDBe:3wi6, PDBj:3wi6
PDBsum3wi6
PubMed24316826
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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