Structure of PDB 3w54 Chain C

Receptor sequence
>3w54C (length=266) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPN
GLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGM
VGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRV
SIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGR
LRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHE
KRLQNSVNPFVVLKKN
3D structure
PDB3w54 Structure of the trypanosome cyanide-insensitive alternative oxidase
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE C E123 E162 H165 E266 E92 E131 H134 E235
BS02 FE C E162 E213 E266 E131 E182 E235
BS03 RNB C R118 C119 L122 L212 A216 T219 Y220 R87 C88 L91 L181 A185 T188 Y189 MOAD: ic50=0.2nM
BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0008199 ferric iron binding
GO:0009916 alternative oxidase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0010230 alternative respiration
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:3w54, PDBe:3w54, PDBj:3w54
PDBsum3w54
PubMed23487766
UniProtQ26710|AOX_TRYBB Alternative oxidase, mitochondrial (Gene Name=AOX)

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