Structure of PDB 3vdr Chain C

Receptor sequence

>3vdrC (length=260) Species: 511 (Alcaligenes faecalis)

MLKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLE
SKFGVKAYYLNADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIE
EFPVDKWNAIIALNLSAVFHGTAAALPIMQKQGWGRIINIASAHGLVASV
NKSAYVAAKHGVVGLTKVTALENAGKGITCNAICPGWVRTPLVEKQIEAI
SQQKGIDIEAAARELLAEKQPSLQFVTPEQLGGAAVFLSSAAADQMTGTT
LSLDGGWTAR

3D structure

• PDB: 3vdr Structure of D-3-hydroxybutyrate dehydrogenase prepared in the presence of the substrate D-3-hydroxybutyrate and NAD+.
• Chain: C
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G15 N114 S142 Y155 K159 I200
• Catalytic site (residue number reindexed from 1): G15 N114 S142 Y155 K159 I200
• Enzyme Commision number: 1.1.1.30: 3-hydroxybutyrate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	C	G11 T13 I16 F36 D63 L64 N90 A91 G92 L113 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193	G11 T13 I16 F36 D63 L64 N90 A91 G92 L113 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193
BS02	NAI	C	G11 T13 I16 F36 D63 L64 N90 A91 G92 L113 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193	G11 T13 I16 F36 D63 L64 N90 A91 G92 L113 S142 Y155 K159 P185 G186 W187 V188 T190 L192 V193
BS03	3HR	C	Q94 S142 H144 K152 Y155 Q196	Q94 S142 H144 K152 Y155 Q196
BS04	AAE	C	Q94 S142 H144 K152 Y155 G186 Q196	Q94 S142 H144 K152 Y155 G186 Q196

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003858 3-hydroxybutyrate dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:3vdr, PDBe:3vdr, PDBj:3vdr
• PDBsum: 3vdr
• PubMed: 19342772
• UniProt: D0VWQ0